Frederick M. Ausubel

Professor of Genetics

Department of Genetics, Harvard Medical School and

Molecular Biologist

Department of Molecular Biology,Massachusetts General Hospital
50 Blossom Street, Wellman 10
Boston, Massachusetts 02114
Phone: (617)726-5950
FAX: (617)726-5949
Email: ausubel@molbio.mgh.harvard.edu

My Current Curriculum Vitae, updated 2/00.

Current Research Interests:

We have developed a novel multi-host pathogenesis system that involves the human bacterial pathogens Pseudomonas aeruginosa, Salmonella typhimurium and Enterococcus faecalis to identify virulence-related genes in bacterial pathogens and defense-related genes in four model genetic hosts: the plant Arabidopsis thaliana, the insect Drosophila melanogaster, the nematode Caenorhabditis elegans, and the mammal, Mus musculus. We have identified a set of novel P. aeruginosa genes required for pathogenesis in all of the model hosts and we have isolated Arabidopsis and C. elegans mutants that exhibit aberrant defense responses when challenged with P. aeruginosa.

Favorite Links:

www.fma.org

Selected Publications List:

Julie M. Stone, Tsuneaki Asai, Jacqueline E. Heard and Frederick M. Ausubel (1999) Investigating the mechanisms of programmed cell death in plants with a toxin from a necrotrophic fungus. In Biology of Plant-Microbe Interactions, volume 2, P.J.G.M. de Wit, T. Bisseling and W.J. Stiekema, eds., APS Press, St. Paul, MN, in press.