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Research Interest:
The resistance or susceptibility of a host plant to a given pathogen
is determined by a complex interplay of plant and pathogen factors.
I am interested in elucidating these factors, the relevant signal transduction
and regulatory pathways, and the resultant alterations in plant metabolism
and physiology using Arabidopsis thaliana as a model host plant. My
research integrates genetic, biochemical, analytical, and informatic
approaches with a long-term goal of modeling disease outcome by coupling
molecular and organismic responses. Recent discoveries include a novel
salicylic acid biosynthetic pathway required for the induction of local
and systemic acquired resistance in plants.
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Publications:
- Gu, Y.-Q., Mary
C. Wildermuth, Chakravarthy, S., Loh, Y.-T., Yang, C., He,X., Han,
Y., and G.B. Martin (2002)
Tomato transcription factors Pti4, Pti5, and Pti6
activate defense responses in Arabidopsis.
Plant Cell 14:817-831. [PubMed]
[Plant
Cell] [PDF]
- Mary C. Wildermuth,
Julia Dewdney, Gang Wu, Frederick
M. Ausubel (2001)
Isochorismate synthase is required to synthesize salicylic
acid for plant defence.
Nature 2001 Nov 29;414(6863):562-5 [PubMed]
[Nature]
[PDF]
- Julia Dewdney
, T.L. Reuber, Mary C. Wildermuth,
A. Devoto, Jianping Cui, L.M. Stutius,
E.P. Drummond, and Frederick M. Ausubel
(2000)
Three unique mutants of Arabidopsis identify eds loci
required for limiting growth of a biotrophic fungal pathogen.
Plant Journal 2000 Oct;24(2):205-18. [PubMed]
[Blackwell
Synergy] [PDF]
- Mary C. Wildermuth
(2000) [MiniReview]
Metabolic control analysis: biological applications
and insights.
GenomeBiology 1(6): reviews 1031.1-1031.5 [PubMed]
[GenomeBiology]
[PDF]
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